相关实验视频
Updated: Jun 28, 2025
10:31
Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
12.4K
[对罕见的过敏原进行过敏原免疫治疗]
Guido Mühlmeier1, Marie-Luise Polk2, Matthias Tisch3
1Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081, Ulm, Deutschland. gmhno@t-online.de.
HNO
|April 19, 2024
概括
罕见的空气过敏原,如菌和动物皮毛,影响了20%的过敏患者. 过敏原特异性免疫疗法 (AIT) 为这些经常被忽视的过敏提供了有效的治疗方法,改善了患者的治疗结果.
科学领域:
- 过敏学和免疫学
- 环境健康 环境健康
背景情况:
- 大约20%的空气过敏原敏感性涉及罕见的过敏原,包括灰,杂草花粉,储存,模具和动物.
- 尽管发病率较低,但对这些罕见的空气过敏原的过敏会导致患者遭受重大痛苦,并且在临床实践中经常被忽视.
- 菌,虫和动物过敏原经常与喘发展有关,这凸显了有针对性的治疗的重要性.
研究的目的:
- 审查当前对罕见气体过敏原的知识,重点关注它们的特征,流行率和过敏原特异性免疫疗法 (AIT) 的疗效.
- 强调诊断和治疗对不太常见的空气过敏原过敏的临床意义.
主要方法:
- 使用MEDLINE (PubMed®) 和谷歌学者数据库进行了系统的文献搜索.
- 该审查综合了各种罕见的空气过敏原的流行率,临床表现和AIT结果的数据.
主要成果:
- 对罕见过敏原的AIT制剂通常是个别配方,而不是标准化.
- 虽然由于患者队伍较小,证据水平可能低于常见过敏原,但实际经验表明有效性良好.
- 对罕见的气体过敏原,特别是菌,虫和动物过敏的患者可以从AIT中受益,特别是当喘存在时.
结论:
- 罕见的空气过敏原是一个重大的临床挑战,需要在日常实践中识别和管理它们.
- 过敏原特异性免疫疗法是患有过敏对罕见的气体过敏原,包括那些与喘相关的患者有价值的治疗选择.
- 可能需要进一步的研究来加强AIT与罕见过敏原的证据基础,但当前的临床经验支持其使用.
相关概念视频
02:06Allergic Reactions
27.3K
Overview
27.3K
01:30Hypersensitivities
622
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
622
00:42Cross-reactivity
31.1K
Overview
31.1K
01:10Antibody Structure
60.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.1K
01:26Antigens Involved in Adaptive Immunity
487
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
487
01:27Allergic Drug Reactions
839
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
839