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Updated: Jun 28, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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针对具有N > 2个结合位点的药物,以目标为媒介的药物排放模型,该药物与一个结合位点的目标结合

Leonid Gibiansky1, Chee M Ng2, Ekaterina Gibiansky3

  • 1QuantPharm LLC, North Potomac, MD, USA. lgibiansky@quantpharm.com.

Journal of pharmacokinetics and pharmacodynamics
|April 19, 2024
PubMed
概括

扩展的目标介导药物排放 (TMDD) 模型现在包括具有多个结合位点 (N-to-one TMDD) 的药物. 像N-to-one QSS这样的近似方法可以准确预测药物行为,从而提供更快的趋同.

关键词:
具有许多结合点的药物.不可逆的绑定近似方法迈凯利斯门近似测试方法非线性药理动力学 非线性药理动力学准平衡的近似方法几乎稳定状态的近似估计.目标介导的药物处置是指通过目标介导的药物处置.

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