在美国成年人中,甲酸盐暴露与代谢功能障碍相关的脂肪肝疾病之间的关系
Junhao Sun1, Siqi Yang1, Yue Zhang2
1Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao, China.
PloS one
|April 19, 2024
概括
暴露于酸盐 (PAE) 可能会增加与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的风险. 在一项大型成人研究中,MEHHP和MEP等特定的甲酸盐代谢物显示出与MAFLD的显著关联.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的健康问题.
- 甲酸盐暴露 (PAE) 和MAFLD之间的联系尚未得到充分理解.
- 酸盐是许多消费品中常见的环境化学物质.
研究的目的:
- 调查暴露于甲酸盐代谢物和MAFLD之间的关联.
- 为了确定与MAFLD风险增加相关的特定甲酸代谢物.
- 探索多个甲酸代谢物对MAFLD风险的综合影响.
主要方法:
- 分析了国家健康和营养检查调查 (2007-2018) 中3,137名成年人的数据.
- 基于美国脂肪肝指数 (US FLI) 和代谢失调的MAFLD诊断.
- 使用波桑回归,受限立方线 (RCS) 和加权量子总和 (WQS) 回归的统计分析.
主要成果:
- 一些酸盐代谢物,包括MECPP,MEP和MEHHP在调整混因子后,与MAFLD有积极关联.
- 综合甲酸盐暴露指数 (WQS) 与MAFLD显著相关 (OR: 1.43).
- MEHHP,MEP,MECPP和单异布甲酸是对综合效应的主要贡献者.
结论:
- 单独或组合暴露于甲酸盐与MAFLD的风险增加有关.
- 这项研究强调了环境化学物质在脂肪肝疾病发展中的潜在作用.
- 需要进一步的研究,以了解这种关联背后的机制.
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