维生素D对抗COVID-19感染,进展和严重程度的作用
Hiba Sh Ahmed1, Hind Sh Ahmed2, Haylim N Abud1
1Department of Microbiology, College of Science, Al-Karkh University for Science, Baghdad, Iraq.
Human antibodies
|April 19, 2024
概括
维生素D缺乏与COVID-19的严重程度和阳性率的增加有关. 补充剂和营养查对于免疫支持至关重要,特别是在危险人群中.
科学领域:
- 营养免疫学 营养免疫学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19病例和死亡人数的增加,需要确定严重后果的危险因素.
- 现有证据表明,维生素D缺乏和COVID-19严重程度之间存在联系,受种族,肥胖和制度化等因素的影响.
研究的目的:
- 研究维生素D和营养状况对抗感染,特别是COVID-19的作用.
- 分析维生素D水平与COVID-19严重程度和死亡率之间的关联.
主要方法:
- 观察性队列,横截面和病例控制研究的系统审查和元分析.
- 包括评估血清维生素D水平在轻度和重度COVID-19病例和死亡率中的研究.
- 分析了将维生素D缺乏症定义为<20 ng/mL的研究及其与严重结果的关联.
主要成果:
- 一项大型回顾性研究 (n=464,383) 发现维生素D水平<30nmol/L与SARS-CoV-2感染 (OR=1.246) 和COVID-19严重程度 (OR=1.513) 的更高风险相关.
- 另一项研究 (n=191,779) 显示,与足够 (8.1%) 或高 (≥55 ng/mL,5.9%) 水平相比,维生素D<20 ng/mL (12.5%) 个体的SARS-CoV-2阳性率更高.
结论:
- 住院COVID-19患者应评估维生素D状态,并考虑补充.
- 营养查和补充对免疫功能至关重要,特别是在具有危险因素的个体和老年人中.
- 对高剂量维生素D及其对恢复的影响进行进一步的研究是有必要的.
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