一个长69个非编码RNA签名预测复发,并作为儿童AML的独立预后因素
Zhiyao Ren1,2,3, Jolien Vanhooren1,2,3, Charlotte Derpoorter1,2,3
1Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Blood advances
|April 19, 2024
概括
一个新的69长非编码RNA (lncRNA) 签名AMLlnc69,改善了儿科急性髓性白血病 (pedAML) 中的复发预测. 这种特征,以及突变状态和白细胞计数,可以指导风险分层,以便更好地管理患者.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 儿科急性髓性白血病 (pedAML) 治愈率有所改善,但30%的患者仍然复发.
- 目前的风险分层方法需要优化.
- 长非编码RNAs (lncRNAs) 在各种癌症中显示出预后潜力.
研究的目的:
- 开发一种新的预后特征,用于使用lncRNA表达来预测pedAML中的复发.
- 在pedAML.中确定无复发生存 (RFS) 的独立预测因子.
- 为改善患者风险分层创建一个名图.
主要方法:
- 一个69 lncRNA签名 (AMLlnc69) 是使用来自TARGET存储库的871 pedAML转录组开发的.
- 使用c指数和接收器操作特征曲线 (AUC) 下的面积来评估预测性能.
- 考克斯回归确定了RFS的独立预测因素,并构建了一个名ogram.
主要成果:
- AMLlnc69的特征显示出对复发风险 (c-index=0.73) 和RFS (AUCs ≈0.77) 的高预测能力.
- 内部验证证实了签名的稳定性 (c指数=0.72,AUCs ≈0.76).
- 诊断时的AMLlnc69,NPM突变和WBC是独立的RFS预测因子,名谱达到0.80.0的c指数.
结论:
- AMLlnc69签名是改进pedAML中复发预测的一个有希望的工具.
- 开发的诺莫图谱提供了一种实用方法,用于将pedAML患者分为风险组.
- 需要对AMLlnc69进行前性验证,以指导临床管理.
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