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相关概念视频

Inhaled Medications01:23

Inhaled Medications

256
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
256
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

133
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
133
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
428

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相关实验视频

Updated: Jun 28, 2025

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
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Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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开发干粉吸入器配方 干粉吸入器

David A V Morton1, David Barling2

  • 1School of Engineering, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, VIC, Australia.

Journal of aerosol medicine and pulmonary drug delivery
|April 19, 2024
PubMed
概括
此摘要是机器生成的。

由于凝聚性粉末系统,设计有效的干粉吸入器 (DPI) 配方是复杂的. 成功的开发需要多学科的团队来解决药物配方,设备和患者的处理,以实现最佳的药物输送.

关键词:
气溶化是一种空气化方法.气溶是一种气溶.干粉吸入器 干粉吸入器流化流化 流化微化的微化.粒子工程是什么?粒子工程是什么?粉末配方的粉末配方粉末表面的修改粉末表面的修改

更多相关视频

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
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Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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相关实验视频

Last Updated: Jun 28, 2025

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Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
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Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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科学领域:

  • 制药科学 制药科学
  • 吸入技术 吸入技术
  • 材料科学 材料科学 材料科学

背景情况:

  • 根据销售价值,干粉吸入器 (DPI) 占据了吸入产品市场的主导地位.
  • 尽管市场领先,但对DPI的基本理解和第一原则设计仍然具有挑战性.
  • 细凝聚性粉末系统的复杂性是这些困难的基础.

研究的目的:

  • 为干粉吸入器 (DPI) 配方提供当代技术视角.
  • 突出设计DPI的科学挑战和复杂性.
  • 审查配方类型,粒子工程和性能因素.

主要方法:

  • 对DPI配方的现有文献和技术观点的审查.
  • 描述各种DPI配方类型及其演变.
  • 对微米大小的药物颗粒的粒子工程过程的分析.
  • 基于载体和无载体的组合的讨论.
  • 检查影响性能的材料,散装和接口属性.

主要成果:

  • 由于凝聚性粉末的固有复杂性,DPI配方开发具有挑战性.
  • 成功的产品开发需要协调的团队方法,整合设备,配方和患者因素.
  • 现有各种配方策略和粒子工程技术用于气溶细药物颗粒.
  • 配方性能严重依赖于材料特性和药物输送特性.

结论:

  • 低估DPI产品开发的难度是一个常见的陷.
  • 考虑设备,配方和患者处理的整体方法对于成功至关重要.
  • 未来的DPI市场选择将平衡技术进步和可负担性.