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Updated: Jun 28, 2025

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NRAS Q61K 的晶体结构在 II 开关附近有一个联结体诱导的口袋

Teklab Gebregiworgis1, Jonathan Yui-Lai Chan2, Douglas A Kuntz2

  • 1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5W9, Canada.

European journal of cell biology
|April 19, 2024
PubMed
概括

研究人员揭示了NRAS Q61K突变蛋白的新型结合部位,为NRAS驱动的癌症提供了新的治疗点. 这一发现推动了对突变NRAS的特定抑制剂的开发,这是一种以前无法治疗的癌症标.

关键词:
晶体结构 晶体结构诱导性适应引起的适应.它们是NRAS和NRAS.瘤原性突变是一种致癌突变.在RAS超级家族中,小GTPases是很重要的.

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