超越表面修改策略控制与植入生物材料和设备相关的感染 - 解决纳米技术提供的机会
Da-Yuan Wang1, Linzhu Su2, Kees Poelstra3
1University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Groningen, the Netherlands; Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300350, PR China.
Biomaterials
|April 19, 2024
概括
生物材料相关感染 (BAI) 表面修饰对治疗无效. 纳米医学通过向生物膜和增强免疫反应,为控制这些持久感染提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 纳米技术 纳米技术
背景情况:
- 生物材料相关感染 (BAI) 由于免疫反应受挫和表面粘附的微生物带来了独特的挑战.
- 目前用于控制BAI的表面修饰策略在治疗中基本上无效,并且在临床验证中面临重大障碍.
研究的目的:
- 批判性地评估生物材料表面修饰对控制生物材料相关感染的有效性.
- 探索用于管理BAI的替代性,更有效的治疗策略,将重点从预防转向治疗.
主要方法:
- 对生物材料表面修饰用于BAI控制的现有文献的审查.
- 对刺激反应的纳米抗微生物和纳米载体用于感染治疗的临床前数据的分析.
主要成果:
- 表面修饰方法在临床环境中取得了有限的成功,这表明BAI治疗的"死胡同".
- 纳米医学策略,包括纳米抗微生物和纳米载体,证明了生物膜透,增强抗药性病原体杀死和免疫调节的潜力.
结论:
- 生物材料表面修饰不是治疗已建立的BAI的可行策略.
- 纳米医学通过解决生物膜和免疫功能障碍,为有效控制BAI提供了一个有希望和更广泛的应用方法.
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