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草甘 (Lycium barbarum glycopeptide) 改善了自身免疫性炎症性疾病中的运动和视觉缺陷

Li Xu¹, Lu Yang¹, Huiming Xu¹

¹Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong Province, PR China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|April 19, 2024

概括

草甘 (Lycium barbarum glycopeptide) (LbGp) 显示神经保护作用,减少神经膜炎光学谱系障碍 (NMOSD) 模型中的星球细胞损伤和脱髓化. 这种传统中医成分为治疗与NMOSD相关的四肢虚弱和视力障碍提供了潜力.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

来自Lycium barbarum的Lycium barbarum糖 (LbGp) 具有神经保护和免疫调节的特性.
神经脊髓炎光学谱系障碍 (NMOSD) 是一种中枢神经系统自身免疫性疾病,导致横向脊髓炎和视神经炎,神经缺陷的治疗选择有限.

研究的目的:

研究LBGp在改善NMOSD病理和神经功能障碍方面的疗效.
阐明LbGp在NMOSD中的治疗作用的潜在机制.

主要方法:

实验性NMOSD模型 (ex vivo和in vivo) 用LbGp进行治疗.
通过旋转棒和步行任务来评估神经功能.
病理性病变,脱髓化 (通过G比EM) 和炎症 (细胞因子,NF-κB信号传递) 通过免疫光学,ELISA和西方斑点测试进行了评估.

主要成果:

在NMOSD模型中,LbGp显著降低了天体细胞损伤,脱髓化和微质激活.
通过保护神经元和视网膜质细胞免受炎症损伤,治疗改善了运动和视觉功能.
通过抑制NF-κB信号传递,LBGp抑制了促炎因子的释放.

结论:

通过减轻关键的病理过程,LbGp证明了NMOSD的治疗潜力.
这些发现支持LbGp作为临床NMOSD治疗的功能性传统中医药的发展.

关键词:

这是一种Lycium barbarum糖 (LbGp).在NF-κB信号传输中.神经炎症是一种神经炎症.神经功能障碍的神经功能障碍神经脊髓炎光学谱系障碍 (NMOSD)

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