暴露于有机酸盐和母婴健康
Sarvenaz Shahin1, Eleanor A Medley2, Mrudula Naidu1
1Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, 10016, USA.
Environmental research
|April 19, 2024
概括
有机酸 (OPEs) 与母亲和儿童的不良健康影响有关,包括发育和神经发育问题. 需要进一步的研究来了解这些广泛的化学物质暴露及其影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖健康 生殖健康
背景情况:
- 有机酸 (OPEs) 是广泛使用的阻燃剂和增塑剂,取代了逐步淘汰的PBDE.
- 在环境中越来越多地检测到OPE,这引发了人们对脆弱人群暴露的担忧.
- 以前的研究表明,与OPE相关的潜在发育毒性.
研究的目的:
- 审查和综合现有的关于OPE暴露与孕产妇,产周和儿童健康结果之间的关联的文献.
- 根据当前的研究,确定特定的OPE和令人担忧的健康结果.
- 突出需要进一步调查OPE对健康的影响.
主要方法:
- 原始研究文章的系统审查.
- 纳入标准重点是研究孕妇,新生儿,儿童和青少年的OPE暴露和健康结果.
- 分析了48个已识别的物品,根据暴露时间 (产前/童年) 和健康结果分类.
主要成果:
- 暴露于OPE可能与不良结果有关,包括怀孕流产,出生体重和妊娠时间的改变,甲状腺功能障碍,代谢和生长异常,神经发育缺陷和免疫系统变化.
- 酸三 (TPHP) 和酸三1,3-二-2- (TDCIPP) 经常被检测到,并与健康结果相关.
- 观察到的健康影响通常因儿童的性别,OPE代谢物和暴露时间而异.
结论:
- 广泛使用OPE及其与广泛的不良健康结果相关的情况引起了重大关注.
- 流行病学研究存在局限性,包括潜在暴露的错误分类和对混因素的调整不足.
- 进一步的研究至关重要,以充分了解OPE带来的风险,考虑混合物和改进暴露评估.
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