探索药物重用在肝脏疾病中的潜力:一项综合性研究
Fares E M Ali1, Mustafa Ahmed Abdel-Reheim2, Emad H M Hassanein3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; Michael Sayegh, Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan.
Life sciences
|April 19, 2024
概括
药物重新定位为寻找肝脏疾病的新疗法提供了一种具有成本效益的方法. 这项研究强调了现有的药物,这些药物显示出治疗肝炎和肝癌等疾病的潜力,尽管需要进一步的研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 药物发现 药物发现 药物发现
背景情况:
- 药物重新定位,即使用已批准的药物用于新的适应症,为新药开发提供了更快,更便宜的替代方案.
- 在科学文献中缺乏标准化定义和不一致的术语,这阻碍了对重用药物的统一数据收集和分析.
- 现有的药物正在越来越多地研究其在治疗各种肝脏疾病的疗效,包括肝炎,肝硬化和癌症.
研究的目的:
- 探索药物再利用的潜力,作为管理肝病的可行策略.
- 识别可能有利于治疗特定肝病的现有或未经研究的药物.
主要方法:
- 文献审查以捕捉肝脏疾病中药物重用假设.
- 对现有药物的分析,研究肝病治疗中的新适应症.
- 利用生物信息学和计算方法来选药物库的潜在候选人.
主要成果:
- 药物再利用显示出作为肝炎,肝硬化,威尔逊病,肝癌和脂肪肝等肝脏疾病的辅助治疗的希望.
- 确定了几种可用或未经研究的药物,对肝脏疾病有潜在的治疗作用.
- 生物信息学工具越来越多地被用于加快药物重新定位候选者的识别.
结论:
- 药物重新定位是一种有价值的策略,有可能解决肝病治疗中的未满足需求.
- 进一步的大规模临床研究是必要的,以验证用于肝脏疾病的药物的有效性和安全性.
- 在药物重用研究中的定义和方法的标准化对于推动该领域的发展至关重要.
相关概念视频
01:16Drug Biotransformation: Overview
2.4K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.4K
01:30Prodrugs
2.6K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Prodrugs help overcome...
2.6K
01:26Drug Discovery: Overview
7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.8K
01:07Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
38
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
A recent model describes pravastatin's hepatobiliary excretion,...
38
01:23Drug Elimination: Non-Renal Routes
2.3K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
2.3K
01:14Hepatic Drug Clearance: Role of Transporters
54
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
54