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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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当地的过敏性鼻炎

Paloma Campo1, Giorgio Walter Canonica2

  • 1U.G.C. Alergología, Hospital Regional Universitario de Málaga, Málaga, Spain.

The journal of allergy and clinical immunology. In practice
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概括
此摘要是机器生成的。

局部过敏性鼻炎 (LAR) 是一种独立于过敏性鼻炎 (AR) 的疾病,其特征是鼻炎和特定的IgE. 鼻腔过敏原挑战 (NAC) 是所有年龄段LAR诊断的关键.

关键词:
过敏性鼻炎是一种过敏性鼻炎.在IgE合成过程中.当地过敏性喘当地的过敏性鼻炎.鼻子过敏原挑战

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科学领域:

  • 免疫学 免疫学 免疫学
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 过敏学 过敏学

背景情况:

  • 局部过敏性鼻炎 (LAR) 与过敏性鼻炎 (AR) 不同,表现为特定的鼻子IgE和炎症.
  • 它严重影响儿童,在地中海地区更为普遍.
  • 随着时间的推移,LAR可能会恶化,并与并发症有关.

研究的目的:

  • 定义局部过敏性鼻炎 (LAR),并将其与过敏性鼻炎 (AR) 的区别.
  • 阐明LAR的生理病理机制和诊断方法.
  • 强调过敏原免疫治疗在LAR管理中的作用.

主要方法:

  • 诊断依赖于临床病史和阳性鼻过敏原挑战 (NAC),负系统IgE.
  • 生理病理学分析包括鼻腔的酸性炎症和分泌物中的特定IgE.
  • 对B细胞标记物 (CXCR3,CXCR4) 和T细胞子集 (Th9,Th2) 的评估.

主要成果:

  • 拉尔表现出增加的鼻乙酸性炎症,酸酶,乙酸乙酸蛋白和特定的IgE在分泌物中.
  • 在B细胞上观察到IgE+ CD38+等离子体和粘膜同源受体 (CXCR3,CXCR4) 的增加.
  • 过敏原免疫疗法在LAR治疗中显示出有效性.

结论:

  • LAR是一个独立的过敏实体,具有明显的免疫病理特征.
  • 鼻腔过敏原挑战 (NAC) 是所有年龄组LAR的黄金标准诊断工具.
  • 提高对NAC的认识和利用对于有效的LAR诊断和管理至关重要.