根据需求的空洞化疗法的最新发展
Karl B Thor1, Lesley Marson2, Mary A Katofiasc2
1Dignify Therapeutics, LLC, Durham, North Carolina kthor@dignifytherapeutics.com.
The Journal of pharmacology and experimental therapeutics
|April 19, 2024
概括
新的药物疗法为神经损伤患者提供按需的膀和肠道控制. 这些治疗旨在减少对导管和手动肠道程序的依赖,改善生活质量.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
背景情况:
- 神经损伤和疾病会损害自发性膀和肠道控制.
- 目前的管理涉及导管和手动肠道程序,这是繁的并有并发症.
- 恢复膀和肠道功能是脊髓损伤患者的首要任务.
研究的目的:
- 讨论新的药物候选人,以满足客户需求的清空疗法.
- 为了解决快速发作的,短时间的空白治疗的未满足的医疗需求.
- 审查膀和肠道功能障碍的新兴疗法.
主要方法:
- 讨论两种候选药物:[lys3,Gly8,-R-γ-lactam-Leu9]-NKA(3-10) (DTI-117) 和素 (DTI-301) 的讨论.
- 通过iontophoresis进行组合药物治疗的临床研究的审查.
- 对神经调节器件的临床前研究进行审查.
主要成果:
- DTI-117是一种神经基因素2受体激活剂,可系统诱导排尿和排便.
- 素 (DTI-301),一个TRPV1受体激动剂,诱导肠道内排便.
- 新兴疗法在诱导排尿和排便方面表现有前途.
结论:
- 按需,药物诱导的排泄疗法可以显著减少对侵入性管理的需求.
- 这些疗法有可能降低医疗保健成本并改善患者的生活质量.
- 恢复膀和肠道控制对于患有神经障碍的人来说至关重要.
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