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相关概念视频

The Micturition Reflex01:26

The Micturition Reflex

584
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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相关实验视频

Updated: Jun 28, 2025

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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根据需求的空洞化疗法的最新发展

Karl B Thor1, Lesley Marson2, Mary A Katofiasc2

  • 1Dignify Therapeutics, LLC, Durham, North Carolina kthor@dignifytherapeutics.com.

The Journal of pharmacology and experimental therapeutics
|April 19, 2024
PubMed
概括
此摘要是机器生成的。

新的药物疗法为神经损伤患者提供按需的膀和肠道控制. 这些治疗旨在减少对导管和手动肠道程序的依赖,改善生活质量.

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科学领域:

  • 神经科学是一个神经科学.
  • 药理学 药理学是指药理学的学科.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 胃肠病学 胃肠病学

背景情况:

  • 神经损伤和疾病会损害自发性膀和肠道控制.
  • 目前的管理涉及导管和手动肠道程序,这是繁的并有并发症.
  • 恢复膀和肠道功能是脊髓损伤患者的首要任务.

研究的目的:

  • 讨论新的药物候选人,以满足客户需求的清空疗法.
  • 为了解决快速发作的,短时间的空白治疗的未满足的医疗需求.
  • 审查膀和肠道功能障碍的新兴疗法.

主要方法:

  • 讨论两种候选药物:[lys3,Gly8,-R-γ-lactam-Leu9]-NKA(3-10) (DTI-117) 和素 (DTI-301) 的讨论.
  • 通过iontophoresis进行组合药物治疗的临床研究的审查.
  • 对神经调节器件的临床前研究进行审查.

主要成果:

  • DTI-117是一种神经基因素2受体激活剂,可系统诱导排尿和排便.
  • 素 (DTI-301),一个TRPV1受体激动剂,诱导肠道内排便.
  • 新兴疗法在诱导排尿和排便方面表现有前途.

结论:

  • 按需,药物诱导的排泄疗法可以显著减少对侵入性管理的需求.
  • 这些疗法有可能降低医疗保健成本并改善患者的生活质量.
  • 恢复膀和肠道控制对于患有神经障碍的人来说至关重要.