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相关概念视频

Types of RNA01:23

Types of RNA

63.6K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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RNA Interference01:23

RNA Interference

26.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.0K
Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K
Riboswitches01:56

Riboswitches

8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
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Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

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相关实验视频

Updated: Jun 28, 2025

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
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Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

Published on: January 30, 2019

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异生物功能的小分子调节RNA功能.

Sandra Kovachka1, Yuquan Tong2, Jessica L Childs-Disney1

  • 1Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 130 Scripps Way, Jupiter, FL 33458, USA.

Trends in pharmacological sciences
|April 19, 2024
PubMed
概括
此摘要是机器生成的。

异构功能化合物通过共价修饰RNA结构来提供增强的RNA向. 本综述强调了这些强大的RNA调节分子的最新进展和未来方向.

关键词:
这是一个RNARNARNARNARNA.喜梅拉斯 (Chimeras) 是一种幻象.药物设计 药物设计它们是异性双功能的.小分子的小分子.转录组 (transcriptome) 是一个转录组.

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Last Updated: Jun 28, 2025

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
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Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 化学生物学 化学生物学

背景情况:

  • 核糖核酸 (RNA) 通过复杂的结构相互作用执行各种细胞功能,包括基因调节和蛋白质合成.
  • 针对RNA结构的小分子已经出现,但简单的结合往往缺乏足够的生物活性.
  • 异位生物功能化合物代表了一种克服简单RNA结合物的局限性的新策略.

研究的目的:

  • 审查最近在RNA向的异构生物功能化合物的进展.
  • 展示这些化合物的代表性案例研究.
  • 确定局限性,并为增强的RNA向分子提出未来开发策略.

主要方法:

  • 关于RNA向性异质生物功能化合物的最新进展的文献综述.
  • 对证明化合物有效性的代表性案例研究的分析.
  • 识别当前领域的关键缺口和局限性.

主要成果:

  • 异位生物功能化合物可以共地与RNA标结合,改变RNA序列,或诱导RNA裂变.
  • 与简单的RNA结合剂相比,这些化合物表现出增强的功能.
  • 代表性的案例研究说明了这种治疗方式的潜力.

结论:

  • 向RNA的异构功能化合物显示出对调节RNA功能的显著前景.
  • 需要进一步开发以解决当前的局限性和优化分子设计.
  • 提出了未来RNA向疗法的战略途径.