在COVID-19期间,神经系统疾病患者的频率和死亡率增加
Candace M Marsters1, Jeffrey A Bakal1,2,3, Grace Y Lam4
1Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Brain : a journal of neurology
|April 19, 2024
概括
患有先前存在的神经疾病的个人在COVID-19感染后面临更高的死亡风险. 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染也增加了急性和后急性阶段新神经系统疾病的风险.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 了解COVID-19的神经并发症对于风险评估和识别新的神经疾病至关重要.
- 以前的研究还没有完全阐明SARS-CoV-2对具有先前神经疾病的个体的影响.
研究的目的:
- 研究患有先发性神经系统疾病的个体中SARS-CoV-2感染的易感性和结果.
- 为了确定COVID-19后神经系统疾病的感染后发病率.
主要方法:
- 一项基于人口的病例控制队列研究,使用2020年3月至2021年6月的卫生服务数据.
- 分析了SARS-CoV-2RNA阳性 (n=177,892) 和RNA阴性 (n=177,800) 成人的匹配队列.
- 在感染后的急性 (<3个月) 和后急性 (3-9个月) 阶段评估了神经系统后果.
主要成果:
- 阳性SARS-CoV-2个体的死亡风险明显更高 (每10万人年中有2140人 vs 922人).
- 病前神经疾病 (帕金森症,痴呆症,发作,脑病,中风) 在COVID-19后显著增加了死亡风险.
- 增加神经系统新发症的风险,包括脑病变,痴呆症,发作和急性阶段的脑雾,持续性,包括炎症性肌肉病和后急性阶段的昏迷.
结论:
- 患有先发性神经系统疾病的个体在感染SARS-CoV-2后死亡风险较高.
- COVID-19与急性和后急性阶段新发神经系统疾病的风险增加有关.
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