青少年异常性关节炎患者的骨健康和体力活动:一个横截面病例对照研究
Egi Vasil1,2, Colleen M Nesbitt3, Clodagh Toomey3,4
1Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N 1N4, Calgary, AB, Canada.
Pediatric rheumatology online journal
|April 19, 2024
概括
与健康的同龄人相比,患有青少年异常性关节炎 (JIA) 的青少年的骨矿物质密度和含量较低. 在JIA患者中,较低的体力活动与这些骨差异无关,但活动仍然对整体健康至关重要.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 骨健康和新陈代谢
- 青少年健康 青少年健康
背景情况:
- 青少年异常性关节炎 (JIA) 与青少年的体力活动减少有关,与典型的发展同龄人相比.
- 较低的体力活动可能会对骨发育和健康产生负面影响.
- 这项研究研究了患有和没有JIA的青少年的骨矿物质含量 (BMC) 和区域骨矿物质密度 (aBMD).
研究的目的:
- 为了比较JIA和对照的青少年之间的全身BMC和aBMD.
- 检查JIA青少年中适度至强度体力活动 (MVPA),瘦身量和骨结果之间的关联.
主要方法:
- 21名患有JIA的青少年和21名年龄和性别匹配的对照组 (10-20岁) 参加.
- 评估包括身高,体重,跳跃距离,加速计测量的MVPA,以及BMC,aBMD和瘦肉质的双X射线吸收计.
- 用多个线性混合效应模型分析了高度调整的z-score.
主要成果:
- 与对照组相比,患有JIA的青少年表现出明显较低的aBMD (p=0.03) 和BMC (p=0.04) z分数.
- 患有JIA的青少年每天减少了22分钟的MVPA,但MVPA与aBMD或BMC没有显著联系.
- 瘦身量与aBMD (p=0.03) 和BMC (p<0.001) 两者都有积极的关联.
结论:
- 与对照人群相比,患有JIA的青少年表现出全身aBMD和BMC的减少.
- 观察到的骨差异并不能通过JIA组中较低的MVPA水平来解释.
- 尽管有这些发现,但促进体育活动对于青少年的福祉仍然很重要.
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