电脑电图引发了小儿的潜力,通过体磁刺激的稳定性
Xiwei She1, Kerry C Nix1, Christopher C Cline2
1Department of Neurology, Stanford University, Stanford, CA, USA.
Scientific reports
|April 19, 2024
概括
在患有的儿童中,可以用更少的脉冲实现与脑电图 (TMS-EEG) 配对的稳定跨磁刺激. 这一发现简化了儿童群体的TMS-EEG研究,缩短了实验时间.
科学领域:
- 神经科学是一个神经科学.
- 临床神经生理学 临床神经生理学
- 儿科神经学 儿科神经学
背景情况:
- 跨磁刺激与脑电图 (TMS-EEG) 结合,是评估神经刺激性和功能连接性的宝贵工具.
- 确定最佳数量的TMS脉冲对于平衡数据质量和实验可行性至关重要,特别是在儿科患者群体中.
- 之前的TMS-EEG研究经常使用大量脉冲 (例如100) 来确保稳定的TMS唤起潜力 (TEP).
研究的目的:
- 研究在患有的儿童中获得稳定的TEP所需的最低脉冲数 (MNP).
- 为了确定影响TEP稳定性的因素,在这个儿科队列.
- 为儿童医学研究设计更高效的TMS-EEG协议提供信息.
主要方法:
- 18名患有自限性的儿童在两天内接受了TMS-EEG.
- 多个100脉冲的TMS块应用于静止电机值 (rMT) 的120%的运动皮层.
- TEP 稳定性是由从所有豆类中获得的"黄金标准" TEP 与80%的一致性所需的 MNP 定义的.
主要成果:
- 稳定的TEP可以在显著低于100个脉冲的情况下实现.
- 后期段 (80-350毫秒) 的TEP比早期段 (15-80毫秒) 更加稳定.
- 当地TEP比全球措施更稳定;稳定性随着年龄的增长和高于rMT的刺激强度而增加.
结论:
- 使用减少脉冲数量的高效的TMS-EEG协议对于研究儿科是可行的.
- TEP 稳定性受到刺激参数和参与者的年龄的影响,而不是半球,块顺序或药物.
- 这项研究为优化儿童神经科学研究中的TMS-EEG方法提供了关键基础.
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