评估COVID-19后的嗅觉恢复:一个横截面研究
Ehab Abou Zaid1, Ahmad Mohamed Eltelety1, Khaled Omar Azooz1
1Al Kasr Al Ainy School of Medicine, Cairo University, Cairo, 11562, Egypt.
概括
许多COVID-19幸存者报告嗅觉恢复,但客观测试显示持续的嗅觉功能障碍. 需要进一步的研究来了解长期的气味丧失影响.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍是COVID-19的一个常见症状.
- 了解气味恢复模式对于患者管理至关重要.
研究的目的:
- 评估COVID-19幸存者的主观和客观嗅觉恢复.
- 为了将嗅觉恢复与COVID-19疾病严重程度相关联.
主要方法:
- 在三个月内评估了200名COVID-19患者.
- 嗅觉功能使用嗅探棒测试和QOD-NS问卷进行测量.
- 使用了主观和客观的评估.
主要成果:
- 37%的人在症状出现时经历了嗅觉功能障碍.
- 主观报告显示,3个月后55%的气味恢复.
- 客观测试显示只有1%的正常功能,在大多数情况下持续存在缺陷.
结论:
- 尽管感知恢复,客观测试显示高率的持续性嗅觉功能障碍后COVID-19.
- 通过客观措施进行长期跟进对于评估气味丧失的真正影响至关重要.
相关概念视频
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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