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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Updated: Jun 28, 2025

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

单细胞地图:一个单细胞的多细胞人类细胞百科全书.

Lu Pan¹, Paolo Parini^2,3, Roman Tremmel^4,5

¹Institute of Environmental Medicine, Karolinska Institutet, 171 65, Solna, Sweden.

|April 19, 2024

概括

科学家们使用单细胞多omics数据创建了一个全面的人体组织地图. 这本交互式在线地图集为研究提供了对胎儿和成人组织细胞特征的深入洞察.

关键词:

流动细胞计量流动细胞计量人类数据库人类数据库质量细胞计量 (Mass cytometry) 是一种测量质量细胞的方法.多个omics的多个omics.一个单细胞地图.单细胞ATAC测序系统的测序单细胞RNA测序的测序方法单细胞免疫特征分析一个单细胞的奥米克.空间转录组学空间转录组学

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Isolation of Nuclei from Flash-Frozen Liver Tissue for Single-Cell Multiomics

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科学领域:

基因组学和生物信息学
人体组织生物学人体组织生物学
多主题研究研究多主题研究

背景情况:

单细胞测序对于理解细胞异质性至关重要.
现有的地图集缺乏对人类组织的综合多主题和空间数据.

研究的目的:

构建人类组织的单细胞多组图.
开发一个互动的基于Web的平台来探索这些数据.
为omics研究提供一个全面的资源.

主要方法:

整合了来自五种单细胞欧米克技术的数据集.
包括空间转录组和两个批量组数据集.
125个健康的成人和胎儿人体组织的表征.

主要成果:

创建一个详细的单细胞多组图的人类组织.
开发一个单细胞地图 (SCA) 网络平台 (www.singlecellatlas.org).
实现跨组织类型和发育阶段的多omics签名的交互式探索.

结论:

单细胞地图提供了前所未有的分辨率到人类组织组成.
该平台作为一个集中的,时间有效的资源,用于各种omics研究.
促进对人类生物学和疾病机制的更深入理解.