在瑞士基于人口的队列中,血和尿液微量元素的参考值
Maïwenn Perrais1,2, Bastien Trächsel3, Sébastien Lenglet1
1Unit of Forensic Chemistry and Toxicology, 658784 University Centre of Legal Medicine Lausanne-Geneva , Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Clinical chemistry and laboratory medicine
|April 20, 2024
概括
本研究使用生物监测确定了瑞士人口中微量元素 (TE) 度的参考值. 这些发现为了解瑞士的TE水平及其对健康的影响提供了关键数据.
科学领域:
- 环境健康 环境健康
- 分析化学 分析化学
- 人体生理学 人体生理学
背景情况:
- 微量元素 (TE) 是必不可少的,但在个人和群体之间有很大的差异.
- 由于缺陷或过剩对健康的后果,对TEs的生物监测至关重要.
- 了解特定人口的TE水平对于公共卫生至关重要.
研究的目的:
- 为瑞士成年人口中广泛的微量元素组建立参考值.
- 为瑞士提供全面的生物监测数据集.
- 评估影响人类TE度的因素.
主要方法:
- 使用ICP-MS.使用1,078名参与者 (18-90岁) 尿液和血样本中24种微量元素的分析.
- 对性别,年龄,BMI和吸烟等共变量的统计评估.
- 对瑞士人口的参考区间 (P50,P95) 的定义.
主要成果:
- 在994个人的血中确定了TE度,在尿液中确定了903个人的TE度.
- 对大多数TEs建立了参考百分位数 (P50,P95).
- 在性别之间观察到TE分布的显著差异,并受到年龄的影响.
结论:
- 这项研究介绍了瑞士首次对微量元素进行大规模生物监测.
- 血和尿液中确定的参考值对瑞士人口有价值.
- 结果与临床指导方针和国际研究结果一致.
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