在LAST标准化项目之后,经过修订的先发性部病变分类的接受度较差
Stefania Montero1, Isabela Sandigo-Saballos1, Cynthia Tom1
1Division of Colon and Rectal Surgery, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA.
The American surgeon
|April 20, 2024
概括
该研究发现,尽管建议采用统一的术语,但内病变的两层高内皮损伤/低内皮损伤 (HSIL/LSIL) 分类在全球范围内下降. 在全球范围内,坚持性仍然不够理想.
科学领域:
- 解剖病理学 解剖病理学
- 妇科病理学 妇科病理学
- 在瘤学瘤学.
背景情况:
- 2013年,下阴道状术语 (LAST) 项目为HPV相关的门病变提出了一种统一的两层命名法 (HSIL/LSIL).
- 全球对这一统一分类的遵守情况尚未评估.
研究的目的:
- 评估采用二级HSIL/LSIL分类与传统三级内皮质新生病 (AIN I/II/III) 系统相比的全球趋势.
- 分析这些分类系统使用的区域差异.
主要方法:
- 在PubMed (2002-2022) 进行了对英语研究的综合文献搜索.
- 研究被按大陆分类,并计算HSIL/LSIL与AIN I/II/III分类使用的流行率.
主要成果:
- 总共有546项研究使用了AIN I/II/III,251项研究使用了HSIL/LSIL.
- 观察到使用双层HSIL/LSIL分类的全球下降趋势具有统计学意义.
- 区域采用率在北美,欧洲,亚洲和拉丁美洲各不相同.
结论:
- 遵守LAST项目的HPV相关门病变的两级分类是不理想的.
- 需要进一步的研究,以了解遵守不良的原因,并制定统一术语和LAST建议集成策略.
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