双边同时磁共振引导的聚焦超声波利切除术,用于危及生命的状况 - - Dystonicus
Vincenzo Levi1, Mario Stanziano2, Carmela Pinto3
1Functional Neurosurgery Unit, Neurosurgery Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
概括
跨脑磁共振引导聚焦超声波 (MRgFUS) 息切除术为脆弱患者的抗药性状况性心肌瘤 (SD) 提供了安全有效的治疗方法. 这种最少的侵入性方法提供了一个可行的替代方案,当开放式手术是不可行的.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 医疗成像医学成像
背景情况:
- 药物耐药性状况性 (SD) 可以通过侵袭性手术治疗,如射频损伤或深度大脑刺激.
- 这些开放的外科选择并不总是适合所有患有SD的患者,因为并发症.
研究的目的:
- 为了评估同时睡眠的双边跨脑磁共振引导聚焦超声波 (MRgFUS) 的安全性和有效性.
- 评估这一程序作为对危及生命的状态 dystonicus 的治疗方法.
主要方法:
- 在全身麻醉下进行双边并发MRgFUS息切除.
- 该程序应用于两名患有泛氨酸激酶相关的神经退行症和GNAO1脑病变的年轻患者.
- 两位患者均患有医疗耐药性SD和严重的并发症,无法进行开放式手术.
主要成果:
- 在MRgFUS后4天和12天内,两位患者的静脉缩状态都消失了.
- 观察到的不良事件,包括手术期间低温和术后过渡性面部,均为轻微的.
结论:
- 在全身麻醉下同时进行双边MRgFUS息切除术是一种安全的治疗选择.
- 这种程序可以作为一个有效的替代品,脆弱的患者与医疗耐药状态 dystonicus.
- 需要进一步的研究来确定MRgFUS息切除术的长期有效性.
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