库库比他素B通过通过激活Nrf2/HO-1通路来抑制NLRP3炎症酶激活和烧亡来减轻骨关节炎的发展

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Chao Lou^1,2, Yuqin Fang^1,2, Yifan Mei³

¹Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Phytotherapy research : PTR

|April 20, 2024

概括

库库比他B (CuB) 通过减少炎症和软骨分解,对骨关节炎 (OA) 有希望. 它通过激活保护通路和抑制炎症过程来起作用,这表明它作为一种OA治疗剂的潜力.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

骨关节炎 (OA) 是一种退行性关节疾病,其特征是炎症和软骨破坏.
库库比他B (CuB) 是一种来自Cucurbitaceae植物的天然化合物,目前正在研究其治疗潜力.

研究的目的:

在骨关节炎 (OA) 的小鼠模型中研究Cucurbitacin B (CuB) 的治疗作用和潜在机制.
通过网络药理学来确定CuB对OA的行动中涉及的关键分子标和途径.

主要方法:

网络药理学分析以确定OA中的CuB的潜在标.
分子对接以评估CuB与关键蛋白质的结合亲和力.
在体外研究细胞以评估CuB对炎症因素和细胞外矩阵 (ECM) 组件的影响.
使用OA小鼠模型进行体内实验,以评估CuB在防止软骨退化的有效性.

主要成果:

网络药理学确定了CuB的54个潜在点,突出了NLRP3炎症和热的途径.
立方体表现出对Nrf2和p65.5的强烈结合亲和力.
在体外,CuB通过减少MMP-13和ADAMTS-5的表达来抑制IL-1β诱导的促炎因素和保护ECM组件.
CuB激活了Nrf2/HO-1通路,并抑制了NF-κB/NLRP3炎症酶介导的烧灭.
在体内,CuB在OA小鼠模型中显著减缓了软骨降解.

结论:

库库比他B (CuB) 有效地抑制胆细胞炎症和ECM降解,从而防止OA的进展.
通过激活Nrf2/HO-1通路和抑制NF-κB/NLRP3炎症酶激活,CuB的治疗效果得到介导.
CuB代表了一种有前途的天然治疗剂,用于骨关节炎.

关键词:

在NLRP3中,NLRP3是NLRP3中的一个.Nrf2 没有任何问题.库库尔比他 B 类药物骨关节炎是一种关节炎.热致灭症是什么?

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