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在清醒的狗中使用非侵入性fMRI和触摸来绘制体感皮层的功能映射
C-N Alexandrina Guran1,2, Magdalena Boch3, Ronald Sladky3
1Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria. alexandrina.guran@univie.ac.at.
Brain structure & function
|April 20, 2024
概括
研究人员使用功能性MRI (fMRI) 将狗大脑中的体感官处理映射出来. 通过触摸激活的大脑区域,包括主要和次要的体感官区域,被确定,揭示了对狗神经解剖学的洞察力.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较解剖学
- 神经成像是一种神经成像.
背景情况:
- 狗是神经科学研究的宝贵模型,特别是在功能性MRI (fMRI) 研究中.
- 对狗功能神经解剖学的有限理解阻碍了对fMRI数据的解释.
- 狗体感官处理的局部化在很大程度上仍然没有特征.
研究的目的:
- 为了精确地定位使用fMRI在清醒,不受约束的狗中参与体感处理的大脑区域.
- 为了研究犬类的触觉感知功能神经解剖学.
- 为了确定主要体感皮层以外的潜在的更高阶处理区域.
主要方法:
- 功能性MRI (fMRI) 对22只狗进行了功能性MRI (功能性MRI) 测试,同时他们的侧翼被用木棒触摸.
- 刺激应用于左侧和右侧,以评估横向化.
- 分析了解剖学和功能数据,以确定激活的大脑区域.
主要成果:
- 在初级 (SI) 和二级 (SII) 体感区域观察到活化,与触觉侧面相反.
- 在带状皮质,小脑,虫子和sylvian gyri中也检测到显著的激活.
- 在大多数狗中发现了体感处理中的功能横向化的证据.
结论:
- fMRI是一种适合于定位狗神经认知处理的技术.
- 狗体感官处理超越SI和SII,涉及与运动控制,认知处理和情感反应相关的领域.
- 这些发现有助于更广泛地了解哺乳动物体内触摸处理.
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