对于被诊断患有癌症的成年人来说,身体功能的哪些方面最重要?
Theresa Coles1, Kate Plyler2, Alexy Hernandez2
1Center for Health Measurement, Department of Population Health Sciences, Duke University School of Medicine, 215 Morris St., Durham, NC, 27701, USA. Theresa.Coles@Duke.edu.
概括
患有癌症的患者优先考虑身体功能的"能力"方面. 了解癌症试验中患者报告的结果 (PRO) 需要具体测量身体功能方面,以获得更好的患者体验.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 以患者为中心的药物开发优先考虑对患者重要的结果,与临床益处定义保持一致.
- 患者报告的身体功能测量在癌症试验中至关重要,用于评估基线功能,治疗益处和副作用影响.
研究的目的:
- 从癌症成年人的角度定性探索身体功能的各个方面.
- 在临床试验环境中,确定该患者群体中最重要的身体功能方面.
主要方法:
- 采用概念诱导和认知面试技术进行半结构面试.
- 涉及72名成年人 (≥22岁) 患有癌症,在6个月内用抗癌药物/生物药物治疗.
- 有目的的抽样确保了与身体功能相关的患者报告结果 (PRO) 项目不同的经验.
主要成果:
- 确定了身体功能的五个方面:能力,困难,限制,满意度和完成.
- 对一半以上的参与者来说,能力是最重要的方面.
- 满足 (18.3%),限制 (14.1%),困难 (5.6%) 和完成 (2.8%) 是下一个最重要的方面.
结论:
- 使用PRO措施评估身体功能方面的特异性对于准确捕捉患者体验至关重要.
- 这些发现对改进癌症临床试验中的身体功能的测量有影响,以更好地反映患者的优先事项.
相关概念视频
Lifestyle Factors and Health
46
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
46
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cognitive Development During Adulthood
94
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
94
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Data Collection III
2.7K
The physical assessment examines the patient for objective data that defines the patient's condition, and aids in formulating the nursing care plan. The purpose of physical assessment is a health status appraisal, which includes identifying health problems, and establishing a database for nursing intervention.
The principles to begin the physical assessment include conducting a comprehensive or problem-related history in a quiet, well-lit room, emphasizing privacy and comfort for the...
The principles to begin the physical assessment include conducting a comprehensive or problem-related history in a quiet, well-lit room, emphasizing privacy and comfort for the...
2.7K


