相关实验视频

Updated: Jun 28, 2025

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
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Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota

Published on: May 23, 2025

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通过分子建模方法发现新的针对PPAR-γ和α-葡萄糖酶的双重向剂:分子对接,分子动态模拟和MM/PBSA分析

Süleyman Kaya1, Gizem Tatar-Yılmaz2, Bedriye Seda Kurşun Aktar3

  • 1Department of Biostatistics and Medical Informatics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

The protein journal
|April 20, 2024
PubMed
概括

使用分子建模设计了新的双目标抗糖尿病药物. 化合物70有效向PPAR-γ和α-葡萄糖酶,显示了改善2型糖尿病治疗的前景,副作用更少.

关键词:
ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME分子对接是分子对接.分子建模分子建模在PPAR-γ中使用PPAR.这就是T2DM.α-葡萄糖化酶的使用.

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