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疑似喘儿童的肺功能特征:对喘诊断的影响
Mireu Park1, Yun Young Roh1, Ha Min Kim1
1Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Disease, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Asian Pacific journal of allergy and immunology
|April 20, 2024
概括
在儿童中诊断喘可能具有挑战性. 这项研究在怀疑喘的儿童中发现了微妙的呼吸道功能障碍,即使没有支气管扩展剂反应或支气管过敏反应,也需要进行额外的测试.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 在儿童中诊断喘依赖于确定可变的呼吸空气流量限制.
- 目前还没有确定的黄金标准测试用于儿童喘诊断.
- 这项研究解决了疑似喘但没有支气管扩展剂反应 (BDR) 或支气管过敏反应 (BHR) 的儿童的诊断缺口.
研究的目的:
- 评估疑似患有喘的儿童的肺功能特征.
- 检查没有典型BDR或BHR的儿童.
- 在这个具有挑战性的子组中确定诊断喘的潜在标志物.
主要方法:
- 使用两个现实世界的儿童队伍进行螺旋测量和支气管挑测试的回顾性观察性研究.
- 在确定的喘,可能的喘和非喘组之间比较螺旋计参数.
- 包括来自Severance医院的1199名儿童和来自Gangnam Severance医院的105名儿童.
主要成果:
- 喘可能发生率为16.8% (原始队列) 和32.4% (外部队列).
- 可能患有喘的组表现出更高的FeNO水平和过敏敏感性.
- 从非喘到确定的喘群体中观察到FEV1,FEV1/FVC,FEF25-75和FEF75的逐步下降 (P < 0.001).
结论:
- 在怀疑患有喘但缺乏BDR和BHR的儿童中存在呼吸道功能障碍的证据.
- 微妙的肺功能障碍可以通过重复的肺功能测试来检测.
- 建议进行过敏查和FeNO等额外的测试,以改善这些儿童的喘诊断.
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