与单独怀孕相比,胎儿生长限制和双胞胎死产之间的关联与单独怀孕相比
A Martínez-Varea1, S Prasad2, J Domenech3
1Department of Obstetrics and Gynaecology, La Fe University and Polytechnic Hospital, Valencia, Spain.
概括
双胞胎怀孕有较高的死产风险. 胎儿生长限制 (FGR) 和小到怀孕年龄 (SGA) 在使用双胞胎特定图表时显著增加双胞胎死产的风险,但不使用单独图表.
科学领域:
- 围产儿医学 围产儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产科 产科 产科 产科 产科
背景情况:
- 双胞胎怀孕与单胎相比,面临着较高的死产风险.
- 胎儿生长限制 (FGR) 是围产死亡率的关键因素,但它对双胞胎和单胞胎的具体影响需要澄清.
研究的目的:
- 调查FGR和小到妊娠年龄 (SGA) 与双胞胎怀孕中的死产之间的关联,与单独怀孕相比.
- 分析这些协会,按分娩时的妊娠年龄和胆管状况分层.
- 为了比较双胞胎特异性与单子出生体重图表的诊断性能,用于FGR和SGA预测双胞胎怀孕中的死产.
主要方法:
- 对95,342例单胎和3,576例双胎妊娠 (1999-2022) 的回顾性横截面研究.
- FGR定义为出生体重<第5个百分点,SGA为<第10个百分点.
- 用于双胞胎怀孕的混合效应后勤回归模型来解释相互依赖的双胞胎;单生子的标准后勤回归. 分析按妊娠年龄和胆管性进行分层分析.
主要成果:
- 在所有妊娠年龄段,SGA和FGR显著与单生子的死产有关.
- 在双胞胎怀孕中,SGA和FGR (使用双胞胎特定图表) 显著增加了所有妊娠年龄的死产风险 (例如,32周前的FGR或5.26).
- 在使用单元出生体重图表时,SGA/FGR与双胞胎死胎之间的关联是无意义的.
结论:
- 胎儿生长限制 (FGR) 和小至妊娠年龄 (SGA) 是单子妊娠中死产的重要危险因素.
- 使用双胞胎特异性出生体重图表对于准确评估双胞胎怀孕中FGR/SGA和死产风险之间的关联至关重要.
- 这些发现强调了针对双胞胎怀孕中胎儿生长异常的量身定制诊断标准的重要性,以减轻死产风险.
关键词:
图表 图表 图表 图表 图表胎儿死亡 胎儿死亡胎儿生长限制 限制胎儿生长在子宫内死亡.多重怀孕是一个多重怀孕.单身怀孕 单身怀孕对于怀孕年龄来说小.一个死产的死产.双胞胎 双胞胎 双胞胎 双胞胎 双胞胎更多相关视频
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