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Updated: Jun 28, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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ProtTrans和多窗口扫描卷积神经网络用于预测蛋白质-交互位点

Van-The Le1, Zi-Jun Zhan1, Thi-Thu-Phuong Vu2

  • 1Department of Computer Science and Engineering, Yuan Ze University, Chung-Li, 32003, Taiwan.

Journal of molecular graphics & modelling
|April 20, 2024
PubMed
概括

这项研究使用先进的机器学习增强了蛋白质-相互作用预测,实现了药物发现和癌症治疗应用的高精度.

关键词:
生物信息学是一种生物信息学.机器学习 机器学习多视图窗口扫描CNNs的多视图窗口预先训练有素的语言模型蛋白质-的相互作用

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Multi-pass Transmembrane Proteins and β-barrels

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α-Helix containing multi-pass transmembrane proteins
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Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
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