手脚皮肤反应与肝细胞癌患者的外部力量之间的关系:一个队列研究
Yukie Tahara1, Ayumi Amemiya1, Ryutaro Kase1
1Department of Health Promotion in Nursing and Midwifery, Graduate School of Nursing, Chiba University, Chiba, Japan.
概括
剪切应力,而不是压力,可能会导致手脚皮肤反应 (HFSR) 在接受氨酸激酶抑制剂 (TKI) 治疗的患者. 建议正确穿鞋以减轻这种常见的副作用.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 生物力学 生物力学
背景情况:
- 手脚皮肤反应 (HFSR) 是氨酸激酶抑制剂 (TKI) 治疗的常见副作用,导致疼痛和功能障碍.
- HFSR主要影响脚部受外部机械力 (如压力和剪切应力) 影响的区域.
研究的目的:
- 调查接受TKI治疗的患者手脚皮肤反应 (HFSR) 的主要诱因是压力或剪切应激.
- 确定在肝细胞癌患者中促进HFSR发展的特定机械因素.
主要方法:
- 一项队列研究涉及患者治疗TKIs治疗肝细胞癌.
- 在行走过程中测量脚底的外力 (压力和剪切应力).
- 使用患者报告的结果和摄影证据评估HFSR严重程度,然后进行统计分析 (t-test,Cox危险分析).
主要成果:
- 在低HFSR组和高HFSR组之间没有发现压力的显著差异.
- 考克斯危害分析表明,第五足头的峰值剪切应力较高和高高压缩风险增加 (HR=1.01,p=0.047) 之间存在统计学上显著的关联.
结论:
- 剪切压力似乎是TKI治疗患者中HFSR发生的潜在因素.
- 临床建议包括对开始TKI治疗的患者进行评估并确保适当的鞋子适合 (直径和宽度),以潜在地减少HFSR发生率.
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