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集成的单细胞转录组和T细胞受体分析揭示了T细胞耗尽在肺结核病中的缺陷

Zilu Wen1, Lin Wang2, Hui Ma1

  • 1Department of Scientific Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

The Journal of infection
|April 20, 2024
PubMed
概括

结核病肺部表现出错误的T细胞耗尽,耗尽的T细胞较少,耗尽标志物减少. 这种功能障碍可能解释了为什么针对T细胞枯竭的免疫疗法可以使结核病恶化.

关键词:
慢性炎症是一种慢性炎症.免疫治疗是一种免疫疗法.单细胞RNA测序的一个细胞.T细胞耗尽的情况结核病是一种疾病.

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