超声波作为研磨或预研磨方法来制备水性悬浮是一种有效的方法吗?
1Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
Journal of pharmaceutical sciences
|April 20, 2024
概括
超声波可以有效地将药物化合物磨到微小的尺寸,作为高压均化的关键预处理步骤. 这种方法通过优化初始颗粒大小的减少来解决实现所需纳米颗粒的局限性.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 高压均质化 (HPH) 是减少活性药物成分 (API) 颗粒大小到纳米尺寸范围的标准.
- HPH的一个关键限制是它依赖于初始颗粒大小,通常需要微化颗粒作为成功纳米化的先决条件.
研究的目的:
- 为了研究超声波作为削或预削技术的有效性.
- 为了降低具有不同变形特性的各种药物化合物的颗粒大小,将其缩小到微缩范围.
主要方法:
- 利用超声波技术进行颗粒大小减小.
- 研究了不同的药物化合物,其特点是它们独特的变形特性.
- 专注于在微缩范围内实现颗粒大小.
主要成果:
- 超声波显示出作为一种有效的削或预削方法的潜力.
- 对于各种药物化合物来说,可以将颗粒大小降低到微化范围.
- 这项研究探讨了化合物变形特性对超声波磨削效率的影响.
结论:
- 超声波为制药化合物预研磨提供了一种可行的替代或补充技术.
- 这种方法可以克服与高压均化过程中初始颗粒大小相关的局限性.
- 通过超声波优化初始颗粒大小,便于随后成功纳米化API.
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