开发和外部验证用于预测急性肺栓塞患者的短期预后的诺姆图
Chao-Wei Ding1, Chao Liu2, Zi-Ping Zhang3
1Department of Respiratory and Critical Care Medicine, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian, 361000, China; Department of Respiratory and Critical Care Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
International journal of cardiology
|April 20, 2024
概括
一种新的诺米图有效预测急性肺栓塞 (APE) 患者的30天死亡率. 这种工具包括年龄,恶性瘤,氧和度,血糖和血管压缩剂的使用,比现有模型提供了更好的临床决策.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 医疗信息学 医疗信息学
背景情况:
- 准确的评估和及时干预对于急性肺栓塞 (APE) 患者至关重要.
- 目前用于APE预后的评分模型复杂,可能缺乏全面的指标.
- 现有模型的局限性阻碍了对APE患者结果的有效评估.
研究的目的:
- 构建和外部验证一个名图,用于预测APE患者的30天全因死亡率.
- 开发一个更准确,更易于使用的工具来评估APE患者的预后.
- 改善APE管理的临床决策.
主要方法:
- 使用了来自重症监护-IV数据库 (1332名APE患者) 的培训队列.
- 使用来自医院APE数据库 (336名患者) 的外部验证队列.
- 开发了一个名图,并使用ROC曲线,校准图和决策曲线分析评估了其预测能力.
主要成果:
- 确定了五个关键预测因素:年龄,恶性瘤,氧和,血糖和血管压缩剂的使用.
- 该名录在培训队列中达到0.765的ROC值,在验证队列中达到0.907的ROC值.
- 在这两个队伍中,诺莫格拉姆的表现超过了肺栓塞严重性指数 (PESI).
结论:
- 开发的名图表在预测APE患者的短期预后方面表现强.
- 比现有模型更简单地应用这个名录,有助于临床决策.
- 该工具为APE患者的管理提供了增强的建议.
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