在SARS-CoV-2肺炎的18个月后持续的肺部异常
C Valenzuela1, L de la Fuente2, S Hernández2
1Servicio de Neumología, Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Radiologia
|April 20, 2024
概括
在SARS-CoV-2肺炎后,HRCT上的持续性肺异常很常见. 许多患者经历了肺部对一氧化碳 (DLCO) 的扩散能力降低,这表明感染后肺功能受损.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是指放射学
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 肺炎可能导致长期呼吸道并发症.
- 高分辨率计算机断层扫描 (HRCT) 对于评估肺损伤至关重要.
- 肺功能测试 (PFTs) 评估肺病对呼吸能力的影响.
研究的目的:
- 在SARS-CoV-2肺炎后18个月的HRCT上描述持续的肺部异常.
- 评估这些异常的程度及其与肺功能的相关性.
- 确定与功能性呼吸系统损伤相关的特定HRCT发现.
主要方法:
- 在SARS-CoV-2肺炎后患有持续性肺部异常的31名患者的前性横截面研究.
- 在感染后平均20.34个月进行HRCT成像.
- 在HRCT发现和PFT (FVC,DLCO,FEV1/FVC) 之间的相关性分析.
主要成果:
- 常见的HRCT发现包括地面玻璃的不透明度 (100%),网膜 (83%) 和引支气管 (69%).
- 在35.4% (FVC < 80%) 和70% (DLCO < 80%) 的患者中观察到肺功能障碍.
- 在HRCT异常 (地面玻璃不透明,网状) 和肺功能受损 (FVC,DLCO,FEV1/FVC) 之间发现了显著的相关性.
结论:
- 持续的间歇性肺部异常在SARS-CoV-2肺炎幸存者的显著亚组中在HRCT上明显.
- 肺部对一氧化碳的扩散能力降低 (DLCO) 是一种常见的后果,影响了70%的评估患者.
- HRCT的发现与功能性呼吸系统缺陷相关,突出显示了长期呼吸系统损害的可能性.
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