乳酸细菌通过增强免疫功能和恢复肠道微生物群平衡来减少子中的细菌性腹
Huimin Li1,2,3, Chaoliang Leng2, Nan Chen1
1College of Animal Sciences, Zhejiang University, 310058, Hangzhou, PR China.
两种益生菌菌株,Enterococcus faecium ZJUIDS-R1和Ligilactobacillus animalis ZJUIDS-R2,通过增强免疫力和恢复肠道菌群平衡,有效减少了断奶的腹并改善了肠道健康.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物益生菌动物益生菌
- 肠道健康研究 研究肠道健康研究
背景情况:
- 乳酸细菌 (LAB) 以它们对动物生长和健康的有益影响而闻名.
- 从健康的子便中分离出Enterococcus faecium ZJUIDS-R1和Ligilactobacillus animalis ZJUIDS-R2,并表现出有希望的体外益生菌性质.
- 以前的研究支持益生菌在预防动物疾病和促进生长方面的作用.
研究的目的:
- 评估Enterococcus faecium ZJUIDS-R1和Ligilactobacillus animalis ZJUIDS-R2在预防断奶子细菌性腹方面的疗效.
- 研究这些特定益生菌菌株对肠道免疫反应和肠道微生物群的影响.
- 评估这些益生菌在减轻肠道损伤和改善子整体健康方面的潜力.
主要方法:
- 两种选择的益生菌菌株,Enterococcus faecium ZJUIDS-R1和Ligilactobacillus animalis ZJUIDS-R2,在10^8 CFU/ml/kg/天的剂量下,在21天内口服给断奶子.
- 在服用益生菌后,子受到一种特定的细菌感染,引起腹.
- 评估的关键参数包括腹发病率,全身炎症反应,肠损伤,抗体水平和肠道微生物群组成.
主要成果:
- 用Enterococcus faecium ZJUIDS-R1和Ligilactobacillus animalis ZJUIDS-R2进行益生菌治疗显著降低了腹发生率和全身炎症.
- 这些干预措施缓解了肠道损伤,并提高了治疗子的抗体水平.
- 观察到特定的微生物转变:Enterococcus faecium ZJUIDS-R1增加了Ruminococcaceae,Ligilactobacillus animalis ZJUIDS-R2促进了Adlercreutzia和Candidatus Saccharimonas,并且它们都减少了Shuttleworthia和Barnesiella,恢复了肠道菌群平衡并增加了短链脂肪酸含量.
结论:
- 肠球菌 (Enterococcus faecium) ZJUIDS-R1和动物菌 (Ligilactobacillus animalis) ZJUIDS-R2显示出作为断奶子益生菌的显著潜力.
- 这些菌株通过提高肠道免疫力,产生有机酸并恢复平衡的肠道微生物群来增强抗病能力.
- 研究结果表明,这些益生菌可以有效地缓解年轻子的腹相关疾病,有助于改善动物健康和福利.
更多相关视频
08:53Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
08:33Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
相关概念视频
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
