在中年和老年2型糖尿病患者中,肉类和脂肪肝之间的关系
Li Quan1, Fang Zhang1, Jing Xu1
1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, department of endocrinology, The first Affiliated Hospital of Xinjiang Medical University, No. 137 of Liyushannan Street, Xinshi District, Urumqi, 830054, China.
Journal of orthopaedic surgery and research
|April 20, 2024
概括
更高的身体质量指数 (BMI),尾骨肌肉指数 (ASMI) 和尿酸 (UA) 水平可能会在2型糖尿病 (T2DM) 患者中预防肉症. 脂肪肝可能会对萨尔科佩尼亚提供一些保护.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 在老年人群中,特别是那些患有2型糖尿病 (T2DM) 的人群中,萨科佩尼亚是一个重大问题.
- 了解影响T2DM患者肉症的因素对于开发有针对性的干预措施至关重要.
- 脂肪肝在调节肉症风险方面的潜在作用需要进一步研究.
研究的目的:
- 在中年和老年患有T2DM的患者中,调查肉类和脂肪肝之间的关系.
- 在这个患者队列中识别与肉类相关的因素.
- 为预防和治疗T2DM中肉症提供理论基础.
主要方法:
- 分析了282名50岁及以上的T2DM患者队列.
- 测量包括身体质量指数 (BMI),四肢和干部肌肉质量,以及萨尔科佩尼亚的诊断标准.
- 使用统计分析,包括多因素后勤回归来评估关系.
主要成果:
- 在sarcopenic和非sarcopenic组之间观察到性别,BMI,脂肪肝患病率,尿酸 (UA),阿兰氨转移酶 (ALT),血糖和血脂的显著差异.
- 较高的BMI,尾骨肌指数 (ASMI) 和UA与降低了肉类的风险有关.
- 脂肪肝的患病率已被注意到,但其直接保护性作用对肉症的确立性尚未确立.
结论:
- 增加的BMI,ASMI和UA水平与T2DM患者骨肌缩的风险降低有关.
- 虽然患有脂肪肝的患者可能表现出对萨尔科佩尼亚的脆弱性降低,但脂肪肝作为预防因素的确切证据有限.
- 这些发现突出了T2DM中萨科佩尼亚管理的潜在生物标志物和保护因素.
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