在新辅助化疗后的HER2-低与HER2-零乳腺癌的生存结果:元分析
Lin-Yu Xia1,2,3,4, Xu-Chen Cao5,6,7,8, Yue Yu1,2,3,4
1The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, 150 meters north of the intersection of Xinjiayuan North Road and Xinjin Road Xinjin Road, Binhai New District, Tianjin, 300060, China.
World journal of surgical oncology
|April 20, 2024
概括
低HER2乳腺癌 (BC) 对新辅助化疗 (NACT) 的反应较低,但治疗后总生存率 (OS) 和无病生存率 (DFS) 较好. 这种生存益处在激素受体阳性组中尤为明显.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- HER2-低与HER2-零乳腺癌 (BC) 后新辅助化疗 (NACT) 的生存结果需要澄清.
- 目前关于这些患者群体治疗反应和生存的证据有限.
研究的目的:
- 系统地审查和分析NACT后HER2-低与HER2-零乳腺癌生存结果的现有证据.
- 为了比较HER2-低和HER2-零BC患者之间的病理完整反应 (pCR),总生存率 (OS) 和无病生存率 (DFS).
主要方法:
- 在PubMed和EMBASE数据库中进行了系统的文献搜索.
- 包含53,714名患者的14项研究被纳入了元分析.
- 根据HER2状态和激素受体 (HR) 状态,分析了生存数据和pCR率.
主要成果:
- 与HER2-零瘤相比,HER2-低瘤的pCR率明显较低,无论HR状态如何.
- 在整体队列中,HER2-低BC表现出比HER2-零BC更长的OS和DFS.
- 虽然在HR-负组中没有观察到OS或DFS差异,但在HR-阳性组中,HER2-低BC显示DFS显著增加.
结论:
- 低HER2乳腺癌对NACT的反应较差,但在整体患者队列中与有利的OS和DFS有关.
- 这些发现表明,在HR阳性亚组中,HER2-低BC的DFS更长.
- 这些结果突出了HER2-低BC患者在NACT后明显的生存轨迹.
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