光学连贯性断层扫描血管学在青光眼中的作用
Maximilian Braun1,2, Chhavi Saini1, Jessica A Sun1
1Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Seminars in ophthalmology
|April 21, 2024
概括
光学连贯断层扫描血管造影 (OCTA) 显示,青光眼患者的微血管减少,与视力丧失相关. 在诊断和监测青光瘤方面,OCTA提供了一个补充作用,特别是当其他方法有限时.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 玻璃眼是不可逆转的视力丧失的主要原因,原因是视网膜质细胞 (RGC) 的逐渐丧失.
- 视神经血液供应受损与玻璃眼病的发病有关.
- 光学连贯断层扫描血管学 (OCTA) 是一种非侵入性工具,用于可视化眼部微血管,使用血流作为对比.
研究的目的:
- 评估OCTA在诊断和监测青光眼中的作用.
- 在使用OCTA的关键解剖区域评估血管密度 (VD).
- 为了比较OCTA的能力与传统方法,如RNFL厚度测量和视野 (VF) 测试.
主要方法:
- OCTA用于测量视神经头部,外皮和黄斑区域的血管密度 (VD).
- 在格劳科马患者的VD测量与未受影响的受试者进行了比较.
- 分析了静脉疾病和功能缺陷 (VF) 之间的相关性.
主要成果:
- 与对照组相比,青光眼患者表现出较低的表面周围毛囊和斑点微血管静脉疾病.
- 由OCTA衍生的VD与VF赤字相关.
- OCTA的诊断能力与RNFL厚度相当,特别是在早期的青光眼中.
结论:
- 通过量化微血管变化,OCTA可以帮助对青光眼的诊断和监测.
- 当RNFL厚度测量有限时,OCTA是有价值的 (例如,高近视,晚期玻璃眼).
- 尽管存在人工制造物的局限性,但OCTA与结构性OCT和VF测试一起作为一种补充工具.
相关概念视频
Glaucoma: Overview
560
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
560
Open Angle Glaucoma: Treatment
440
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
440
Angle Closure Glaucoma: Treatment
485
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
485


