超性缺氧作为缺血性中风后患者的康复方法
Tatiana M Alekseeva1, Maria P Topuzova1, Vladimir P Kulikov2
1Department of Neurology with Clinic, V.A. Almazov National Medical Research Center, Saint-Petersburg, Russia.
Neurological research
|April 21, 2024
概括
在缺血性中风患者中,呼吸训练与超体缺氧显著改善神经功能. 这种方法对早期的神经康复有希望,在中风后48-72小时内增强恢复.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 实验研究表明,高卡普尼性缺氧提供了比正常卡普尼性缺氧更大的神经保护.
- 呼吸训练与超体缺氧对脑儿童的神经系统产生了积极的影响.
- 结合中度高头和缺氧的假设是有利于早期的后缺血性中风康复.
研究的目的:
- 为了评估呼吸训练的有效性,在患有缺血性中风后的患者中,高卡普尼克缺氧.
- 在急性缺血性中风患者中,比较超体缺氧与安慰剂的神经康复效应.
主要方法:
- 一项随机,三重盲,安慰剂控制的研究,涉及102名缺血性中风患者 (年龄为63.07±12.1岁) 在中风发作后48-72小时内.
- 实验组 (n=50) 每天接受20分钟的呼吸训练,并进行7~11个会话的高氧 (FetCO2 5~6%,FetO2 15~16%).
- 对照组 (n=52) 接受了安慰剂治疗,使用了大气空气的修改设备. 在干预前和后进行了神经学评估.
主要成果:
- 与安慰剂组相比,超性缺氧组在神经功能上显示出明显更大的改善.
- 关键指标有所改善:NIHSS得分降低了40%,mRS得分降低了35%,B-ADL-I和RMI指数分别提高了26%和36%.
- 认知和情绪评估也有利于干预组:MoCA得分高出13%,HADS和BDI-II得分分别低出35%和25%,MMSE得分增加了54%.
结论:
- 使用超体缺氧的呼吸训练有效地提高了缺血性中风患者神经系统的功能状态.
- 超性缺氧是一种有前途且有效的神经康复方法,用于早期干预,在中风发作后48-72小时内适用.
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