瑞典先进非小细胞肺癌的第一线治疗模式和结果:以免疫疗法为重点的基于人口的现实研究
Gunnar Wagenius1, Anders Vikström2, Anders Berglund3
1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Theme Cancer, Medical Unit Head and Neck, Lung, and Skin Tumors, Thoracic Oncology Center, Karolinska University Hospital, Stockholm, Sweden. gunnar.wagenius@regionstockholm.se.
Acta oncologica (Stockholm, Sweden)
|April 21, 2024
概括
在瑞典,大多数晚期非小细胞肺癌 (NSCLC) 患者接受PD-L1测试. 在NSCLC中使用PD-(L) 1抑制剂治疗的现实结果显示,生存率与临床试验相似.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床研究 临床研究
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 的治疗已经被免疫疗法所改变.
- 了解现实世界的治疗模式和结果对于优化患者护理至关重要.
研究的目的:
- 为了评估瑞典晚期NSCLC患者的PD-L1测试率.
- 在这个人群中描述PD-L) 1抑制剂的治疗模式和现实结果.
主要方法:
- 来自瑞典国家肺癌登记处 (2017-2020年) 的数据,用于晚期NSCLC患者 (ECOG PS 0-2).
- 使用Kaplan-Meier方法分析PD-L1测试,一线治疗模式 (基于的与基于PD-L) 的治疗) 和整体存活率 (OS).
主要成果:
- 观察到高PD-L1测试率 (85-86%),随着时间的推移而增加.
- 从基于的转向基于PD-L) 1的第一线疗法.
- 单独治疗PD-(L) 1抑制剂的中位数生存期:18.6个月 (NSQ) 和13.3个月 (SQ).
- PD-(L) 1 抑制剂 + 化疗的中位 OS: 24.0 个月 (NSQ).
结论:
- 在瑞典,大多数晚期NSCLC患者都会进行PD-L1表达的测试.
- 接受一线PD-L) 1抑制剂治疗方案的患者的实际整体存活率与临床试验的关键发现一致.
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