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在COVID-19中NLR和PLR的预后意义:一个多队列验证研究

Marta Colaneri^1,2, Camilla Genovese³, Federico Fassio⁴

¹Department of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.

Infectious diseases and therapy

|April 21, 2024

概括

中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 有效预测COVID-19患者的严重结果. 高负预测值 (NPV) 证实了它们在识别患有严重疾病进展可能性较低的个体中的有用性.

科学领域:

医学研究医学研究
临床诊断临床诊断临床诊断
炎症标志物是一种炎症标志物.

背景情况:

最近的研究表明,中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 的预后值对于严重的COVID-19结局.
在新队列中验证已建立的NLR和PLR截止值对于通用性至关重要.

研究的目的:

在新的COVID-19患者队列中验证先前确定的中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 截止值.
评估NLR和PLR作为严重COVID-19结果的预后指标的概括性.

主要方法:

这是一项回顾性队列研究,涉及两家医院的3599名COVID-19患者.
评估NLR和PLR对非侵入性通风 (NIV) /CPAP,侵入性通风 (IV) 和死亡的预测能力.
单独计算男性和女性队列的灵敏度,特异性,PPV和NPV,使用既定的截止值.

主要成果:

对于NLR和PLR的敏感度值低于整个队列的特异性值.
积极的预测值 (PPV) 通常低于63%,而负预测值 (NPV) 超过了PLR的68%和NLR的72%.
与NIV/CPAP使用相比,NLR和PLR在严重结局 (例如死亡,IV) 中显示出更高的NPV.

结论:

研究结果证实了NLR和PLR截止值在不同人群中的可靠性和适用性.
高的NPV凸显了NLR和PLR在识别患有较低严重COVID-19风险的患者中的实用性.
这些炎症标志物有助于在公共卫生紧急情况下进行风险分层和资源分配.

关键词:

在 COVID-19 疫情中,中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.预测指标预测指标验证研究的验证研究.

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