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莫林,一种异硫酸盐调节乳腺癌细胞中的多个细胞信号分子

Ankit Srivastava¹, Shruti Mishra¹, Avadhesh¹

¹Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Cellular signalling

|April 21, 2024

概括

禁忌素 (PHB) 表达影响乳腺癌存活率. 莫林 (MG) 是一种天然化合物,通过诱导细胞亡和抑制关键的生存蛋白质来抑制癌细胞生长,提供了潜在的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

禁忌素 (PHB) 是一种类分子,对乳腺癌的作用尚不清楚.
在各种癌症中,PHB表达变化,与减少整体存活率相关.

研究的目的:

研究PHB在乳腺癌中的作用.
为了评估Moringin (MG) 的抗癌作用,Moringa oleifera种子中的异基酸盐.

主要方法:

在癌症患者中评估PHB表达.
用MG治疗的MCF-7和MDAMB-231乳腺癌细胞.
使用的亡试验 (AO/PI,胺外化,细胞循环,DAPI染色).
分析的蛋白质表达 (细胞染色体c,p53,caspase-7,幸存者,BCL-2,BCL-xL,NF-κB). 通过分析的蛋白质表达 (细胞染色体c,p53,caspase-7,幸存者,BCL-2,BCL-xL,NF-κB).
测量了线粒体膜潜力和反应性氧物种 (ROS).
研究了lncRNA调制和p65核转位.

主要成果:

PHB 变化与患者存活时间减少相关.
MG抑制了乳腺癌细胞的生长,通过线粒体通路诱导了细胞亡.
MG抑制了促生存的蛋白质,并调节了NF-κB信号传递和lncRNAs.
MG治疗增加了癌细胞中的ROS生成.

结论:

PHB在乳腺癌的进展中起着重要作用.
莫林通过向多种途径,包括诱导亡和抑制NF-κB,表现出强大的抗癌活性.
MG显示出作为乳腺癌治疗剂的潜力.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.乳腺癌乳腺癌乳腺癌炎症炎症是一种炎症.异二酸盐是什么异二酸盐长的非编码RNA是什么?更多关于 moringin 的文章禁止使用这种药物.

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