产生KPC-2的肠道细菌从即食食品到住院患者
Bianca Lara Venâncio de Godoy1, Marlon do Valle Barroso1, Yasmin Fontoura de Azeredo Lourenção2
1Faculdade de Medicina de São José do Rio Preto, Centro de Investigação de Microrganismos, São José do Rio Preto, SP, Brazil.
概括
准备食用的食品可以将多药耐药细菌传递给住院患者. 这项研究在患者食品中发现了产生β-乳糖酶的肠道细菌,突出显示了医院感染的饮食风险.
科学领域:
- 微生物学 微生物学
- 食品安全 食品安全
- 传染性疾病 传染性疾病
背景情况:
- 住院患者由于免疫力受损,容易感染感染.
- 食品是众所周知的多药耐药细菌的储存库.
研究的目的:
- 在住院患者食用的即食食品中检测产生β-乳糖酶的肠道细菌.
- 评估这些细菌在医院环境中引起感染的潜力.
主要方法:
- 分析51个准备食用的蔬菜和肉样本.
- 鉴定和抗微生物敏感性测试的肠道细菌分离物.
- 查β-乳酸酶基因和pH耐受性测试.
- 全基因组测序 (WGS) 用于特征特定的分离物.
主要成果:
- 检测带有扩展谱β-lactamases,cephalosporinases和carbapenemases基因的肠杆菌分离物.
- 所有检测到的分离物体都表现出对人类胃肠道中发现的pH水平的耐受性.
- 全基因组测序确定了与人类病原体密切相关的血统的KPC-2载体.
结论:
- 饮食摄入代表了抗微生物耐药细菌传播到脆弱患者群体的重要途径.
- 这些发现强调了在医院感染控制战略中考虑食品安全的必要性.
- 污染的食品在医疗环境中构成抗生素耐药性传播的风险.
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