在老鼠模型中减少骨质整合和脱皮是由于细胞对多尺度微结构表面的反应受损而导致的
Jingyao Deng1, David Joshua Cohen1, Enrique B Matias1
1Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.
概括
在植入体手术前骨卸载会损害骨愈合和骨质整合. 这表明,患者的不运动和肌肉功能的病史对于成功的植入物结果至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科的研究研究.
- 再生医学是一种再生医学.
背景情况:
- 固定导致骨损失和肌肉缩,增加跌倒风险和对植入物的需求.
- 骨卸载影响骨重塑,可能影响植入物骨质整合.
- 在不使用条件下了解早期的骨质整合对于植入物治疗至关重要.
研究的目的:
- 为了研究骨卸载对改造砂吹,大砂,酸蚀刻 (modSLA) 植入物早期骨质整合的影响.
- 要确定在植入物放置前或植入物放置期间确定不使用是否会影响骨质整合.
- 在没有负荷的条件下探索潜在的受损骨整合的细胞机制.
主要方法:
- 研究人员使用了两种老鼠模型:在植入植入器放置期间使用造的坐骨神经切除术 (研究1) 和植入前的坐骨/股骨神经切除术 (研究2).
- 修改后的沙吹,大砂,酸蚀刻 (modSLA) 植入物被放置在远距离的股骨形状.
- 微计算机断层扫描 (MicroCT) 和组织形态测量被用来评估骨体积和骨质整合.
主要成果:
- 在植入之前建立骨卸载显著减少了椎骨和骨质整合.
- 来自无负荷骨的骨质母细胞在modSLA表面表现出受损的分化,表明细胞水平的缺陷.
- 当不使用前插入植入物时,植入物骨质整合受到损害.
结论:
- 机械卸载和肌肉功能受损的病史会对植入物骨质整合产生负面影响.
- 在没有负荷的条件下,细胞再生能力降低是植入物性能差的一个关键因素.
- 在优化植入物治疗时,应考虑患者的手术前机械和功能状态.
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