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Updated: Jun 28, 2025

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

这项PACIFIC-PRESERVED (PhenomApping,Classification and Innovation for Cardiac dysfunction in patients with heart

Jean-Sébastien Hulot¹, Philip Janiak², Philippe Boutinaud³

¹Université Paris Cité, INSERM, PARCC, 75015 Paris, France; CIC1418 and DMU CARTE, Hôpital Européen Georges-Pompidou, AP-HP, 75015 Paris, France.

Archives of cardiovascular diseases

|April 21, 2024

概括

这项PACIFIC-PRESERVED研究通过深度表型患者重新定义了心力衰竭与保存的喷射分数 (HFpEF). 这项研究旨在确定不同的HFpEF子组,并提高对其复杂病理生理学的理解.

科学领域:

心脏病学心脏病学
生物医学工程生物医学工程
数据科学数据科学数据科学

背景情况:

保存喷射分数 (HFpEF) 的心力衰竭是一种复杂且不太了解的疾病.
现有的定义不能完全捕捉HFpEF病理生理学的异质性.

研究的目的:

通过全面的,多维的深度表型重新定义HFpEF的表型谱.
使用机器学习将HFpEF重新分类为不同的子组.
推进对HFpEF机制的理解,并确定新的治疗点.

主要方法:

展望性,多中心队列研究 (PACIFIC-PRESERVED),包括HFpEF,心力衰竭与减少喷射率 (HFrEF) 和对照组.
多维深度表型:临床评估,成像 (CMR,回声,CT),生物标志物,动脉硬性和可穿戴传感器数据.
现实生活中的14天监测使用连接的服装来收集生理和活动数据.
集中的数据分析,采用机器学习来识别患者子组和发现途径.

主要成果:

这项研究将为HFpEF研究产生一个独特的,丰富的数据集.
预计机器学习分析将揭示新的HFpEF子组.
预计将确定新的生物途径和HFpEF的分子标.

结论:

太平洋保存是一个开创性的HFpEF现象映射研究.
使用先进的分析技术和新的数据收集方法.
将提供关键的见解,以更好地定义HFpEF和分层患者.

关键词:

诊断诊断诊断诊断诊断心脏衰竭是因为心脏衰竭.心力衰竭与保存的喷射分数的心脏衰竭机器学习机器学习现象映射 (phenomapping) 是一种现象映射.

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相关概念视频

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...