杆菌和喉回流性疾病之间的关联:系统性审查和元分析
Siwei Liu1, Changjiang Li2, Siyan Xu2
1Department of Otorhinolaryngology Head and Neck Surgery, Pujiang Hospital, Minhang Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
杆菌 (H pylori) 感染与喉回流病 (LPRD) 的风险增加有关. 这一系统性审查发现LPRD患者的H pylori比率更高,这表明存在联系. 需要进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 在喉回流性疾病 (LPRD) 病原发生过程中,Helicobacter pylori (H pylori) 的作用受到争议.
- 现有的研究提出了关于这种关联的相互矛盾的证据.
研究的目的:
- 系统地审查和对现有研究进行元分析,以调查H pylori感染和LPRD之间的潜在关联.
- 量化患有和没有LPRD的患者中H pylori的风险和患病率.
主要方法:
- 一个全面的系统审查和发表的研究的元分析.
- 搜索了主要的数据库,包括PubMed/MEDLINE,EMBASE,Cochrane图书馆,科学网和临床试验.gov.gov.
- 包括的研究集中在LPRD诊断或治疗H pylori感染患者.
主要成果:
- 在分析中包括了15项研究.
- 在H pylori感染和LPRD之间发现了显著的关联 (RR=1.35,P=0.002).
- 与非LPRD患者 (35%) 相比,LPRD患者 (49%) 的H pylori患病率更高.
结论:
- 有限的证据表明,增加的H pylori感染和LPRD风险之间存在关联.
- 结果的异质性可能是由于人口差异,诊断方法和测试变化.
- 建议进行进一步的精心设计的研究,以探索H pylori根除在LPRD治疗中的有效性.
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