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早期卵巢衰竭 (POI) 的女性的性功能:系统性审查和元分析

Charissa van Zwol-Janssens¹, Hester Pastoor¹, Joop S E Laven¹

¹Erasmus MC, Division Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, PO Box 2040, 3000 CA Rotterdam, the Netherlands.

|April 21, 2024

概括

与对照组相比,早产卵巢缺陷 (POI) 的女性经历了显著减少的性功能. 这一发现凸显了讨论性健康和向被诊断为POI的妇女提供咨询的必要性.

科学领域:

生殖内分泌学生殖内分泌学
妇女健康妇女健康
心理性医学心理性医学

背景情况:

早发性卵巢缺陷 (POI) 影响40岁之前的卵巢功能,与情绪和性功能障碍有关.
关于POI对女性性功能的特定影响的高质量证据有限.
这项研究解决了对POI妇女性功能的全面评估的需要.

研究的目的:

系统地审查和对POI妇女性功能现有证据进行元分析.
将POI女性的性功能与没有POI女性的性功能进行比较.
提供POI对性功能影响的定量评估.

主要方法:

在多个数据库 (EMBASE,Medline,科学网,Cochrane,PsychInfo,Google Scholar) 进行系统搜索,截至2023年1月.
包括10项研究进行审查和5项研究 (352名女性) 进行元分析.
随机效应模型用于分析,报告Hedges的g效应大小和95%置信区间.

主要成果:

十项研究中有八项研究得出结论,POI的女性性功能下降.
平均整体效果大小 (Hedges' g = -0.72) 表明POI女性的性功能显著降低.
接受激素替代疗法 (HRT) 的女性显示出更大的效果大小 (Hedges' g = -0.82),表明了潜在的益处.

结论:

与同龄人相比,早产卵巢衰竭的女性表现出性功能下降.
医疗保健提供者应该主动地与被诊断为POI的妇女讨论性健康问题.
对于与POI相关的性功能障碍的妇女,建议提供心理咨询.

关键词:

更年期绝经绝经一个警察.过早的卵巢功能不充分性功能障碍性功能障碍性功能障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性障碍性性功能性功能性功能

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