内皮功能障碍和外围动脉疾病与慢性脏病中肉症的关联
Bang-Gee Hsu1,2, Chih-Hsien Wang1,2, Yu-Hsien Lai1,2
1Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Journal of cachexia, sarcopenia and muscle
|April 21, 2024
概括
内皮功能障碍和外周动脉疾病 (PAD) 与慢性脏病 (CKD) 患者的麻症有关. 血管功能障碍在患有3-5阶段CKD的个体中发展皮症中起着关键作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 血管生物学 血管生物学
- 老年病的医生 老年病的医生
背景情况:
- 慢性病 (CKD) 与内皮功能障碍和外周动脉疾病 (PAD) 有关,影响骨肌肉微 perfusion.
- 这些血管问题在CKD患者中很常见,可能会导致肉症,肌肉质量和力量的损失.
研究的目的:
- 为了研究内皮功能障碍,PAD和非透析CKD阶段3-5的患者的肉症之间的关联.
- 在这个患者群体中识别预测肉症的血管生物标志物.
主要方法:
- 一项对420名非透析CKD患者 (3-5阶段) 的横截面研究.
- 用亚洲麻症工作组2019年标准评估了麻症.
- 内皮功能和PAD分别通过血管反应率指数 (VRI) 和脚-手腕指数 (ABI) 进行测量.
- 包括ICAM-1,VCAM-1和ET-1在内的生物标志物被分析为一个子组.
主要成果:
- 在24.5%的患者中出现了肉类症.
- 麻症患者的ABI和VRI值显著降低.
- 在患有肉症的患者中观察到更高的ICAM-1,VCAM-1和ET-1水平.
- 较差的VRI和ABI独立地与肉症相关,在患有这两种疾病的人群中观察到的风险最高.
结论:
- 内皮功能障碍和PAD在非透析CKD患者中独立与缩症相关.
- 血管功能障碍似乎是这种队列中 Sarcopenia 的发展的一个重要因素.
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