低手术重量与儿科水脑患者的ETV失败有关
Hannah Black1, Benjamin Succop2, Caren M Stuebe3
1School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, USA.
Neurosurgical review
|April 21, 2024
概括
手术时的体重,而不是年龄,是内镜第三室内静脉切除术 (ETV) 在儿科脑水症中成功的关键预测因素. 体重小于4.9公斤的婴儿有更高的ETV失败率,重量是治疗候选人的关键因素.
科学领域:
- 神经外科 神经外科
- 儿科手术 儿科手术
- 医疗技术 医疗技术 医学技术
背景情况:
- 通过内镜第三腔静脉切除术 (ETV) 治疗的儿科头症在年轻患者中显示出更高的失败率.
- 围绕手术的变量如妊娠年龄,时间年龄,出生体重和手术体重可能会影响ETV的结果.
- 了解这些因素对于优化婴儿治疗策略至关重要.
研究的目的:
- 调查术后变量的影响,特别是妊娠年龄,时间年龄,出生体重和手术体重,对儿科水脑的ETV失败率的影响.
- 确定婴儿和幼儿中ETV失败的预测因素.
- 为了确定手术时的体重是否比年龄更强有力的预测因素.
主要方法:
- 在2010年至2021年期间,对47名接受ETV治疗的儿科患者进行了回顾性评估 (带或不带胆脉烧结).
- 分析使用考克斯回归用于独立预测因素和卡普兰-梅尔生存曲线用于时间到事件结果.
- 评估妊娠年龄,时间年龄,出生体重和手术体重作为ETV失败的潜在预测因素.
主要成果:
- 整体ETV失败率为66%,中位失败时间为术后36天.
- 6个月以下的患者的失败率为80%,而6个月以上的患者的失败率为41%.
- 手术体重与ETV失败有显著的反向关联 (多变量HR 0.76);体重<4.9公斤是预测失败的最佳切线. 时间和妊娠年龄都不是有意义的预测因素.
结论:
- 手术时的体重,特别是<4.9公斤,比慢性或妊娠年龄更强大地预测了儿科水头症中ETV失败的因素.
- 年轻的患者通常经历更高的失败率,但体重似乎是一个更关键的术后变量.
- 需要对更大的队列进行进一步的研究,以确认体重在确定婴儿ETV候选症中的独立作用.
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