介质干细胞/干细胞的效力:捐赠者的性别是否重要?
Ghada Maged1, Menna A Abdelsamed2, Hongjun Wang3,4
1Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
Stem cell research & therapy
|April 21, 2024
概括
捐赠者的性别显著影响介质干细胞/干细胞 (MSC) 的功效和疗效. 本次审查强调了需要考虑捐赠者的性别作为优化MSC基细胞疗法和组织工程应用的关键因素.
科学领域:
- 细胞生物学 细胞生物学
- 再生医学是一种再生医学.
- 免疫学 免疫学 免疫学
背景情况:
- 介质细胞干/干细胞 (MSCs) 由于分化,免疫调节和组织保护,显示出治疗的前景.
- 诸如细胞来源,供体年龄和批量等因素会影响MSC的功效.
- 捐赠者的性别是影响MSC特征的潜在,但尚未研究的因素.
研究的目的:
- 审查有关与捐赠者性别相关的MSC异质性的现有文献.
- 强调供体性别在MSC功效和细胞治疗功效方面的重要性.
主要方法:
- 已发表研究的文献综述.
- 分析MSC属性的与供体性别相关的变化.
主要成果:
- 已发表的研究表明,MSC的异质性基于捐赠者的性别.
- 捐赠者的性别影响MSC特征,影响其治疗潜力.
结论:
- 捐赠者的性别是一个关键的,经常被忽视的,影响MSC功效的因素.
- 披露捐赠者的性别对于标准化和改进基于MSC的疗法至关重要.
相关概念视频
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
01:27Source And Potency Of Stem Cells
4.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.8K